A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes

Gamma aminobutyric acid(GABA) is synthesized by glutamate decarboxylase(GAD) in β-cells. Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, while GAD immunization may also preserve β-cells. W...

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Detalles Bibliográficos
Autores principales: Martin, Alexandra, Mick, Gail J., Choat, Heather M., Lunsford, Alison A., Tse, Hubert M., McGwin, Gerald G., McCormick, Kenneth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790014/
https://www.ncbi.nlm.nih.gov/pubmed/36566274
http://dx.doi.org/10.1038/s41467-022-35544-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790014/
https://www.ncbi.nlm.nih.gov/pubmed/36566274
http://dx.doi.org/10.1038/s41467-022-35544-3

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