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Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection

BACKGROUND: SARS-CoV-2 has a significant impact on healthcare systems all around the world. Due to its high pathogenicity, live SARS-CoV-2 must be handled under biosafety level 3 conditions. Pseudoviruses are useful virological tools because of their safety and versatility, but the low titer of thes...

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Detalles Bibliográficos
Autores principales: Wang, Zeng, Zhong, Kunhong, Wang, Guoqing, Lu, Qizhong, Li, Hexian, Wu, Zhiguo, Zhang, Zongliang, Yang, Nian, Zheng, Meijun, Wang, Yuelong, Nie, Chunlai, Zhou, Liangxue, Tong, Aiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790109/
https://www.ncbi.nlm.nih.gov/pubmed/36577450
http://dx.doi.org/10.1016/j.gene.2022.147144