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Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel

The c subunits, which constitute the c‐ring apparatus of the F(1)F(O)‐ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well‐known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl‐prolyl cis‐trans isomerase. On the l...

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Detalles Bibliográficos
Autor principal: Nesci, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790210/
https://www.ncbi.nlm.nih.gov/pubmed/35532281
http://dx.doi.org/10.1002/prot.26383