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Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel
The c subunits, which constitute the c‐ring apparatus of the F(1)F(O)‐ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well‐known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl‐prolyl cis‐trans isomerase. On the l...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley & Sons, Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790210/ https://www.ncbi.nlm.nih.gov/pubmed/35532281 http://dx.doi.org/10.1002/prot.26383 |
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author | Nesci, Salvatore |
author_facet | Nesci, Salvatore |
author_sort | Nesci, Salvatore |
collection | PubMed |
description | The c subunits, which constitute the c‐ring apparatus of the F(1)F(O)‐ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well‐known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl‐prolyl cis‐trans isomerase. On the loop, which connects the two hairpin α‐helix of c subunit, is present the unique proline residue (Pro (40)) that could be a biological target of CyPD. Indeed, the proline cis‐trans isomerization might provide the switch that interconverts the open/closed states of the pore by pulling out the c‐ring lipid plug. |
format | Online Article Text |
id | pubmed-9790210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97902102022-12-28 Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel Nesci, Salvatore Proteins Perspective The c subunits, which constitute the c‐ring apparatus of the F(1)F(O)‐ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well‐known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl‐prolyl cis‐trans isomerase. On the loop, which connects the two hairpin α‐helix of c subunit, is present the unique proline residue (Pro (40)) that could be a biological target of CyPD. Indeed, the proline cis‐trans isomerization might provide the switch that interconverts the open/closed states of the pore by pulling out the c‐ring lipid plug. John Wiley & Sons, Inc. 2022-05-19 2022-11 /pmc/articles/PMC9790210/ /pubmed/35532281 http://dx.doi.org/10.1002/prot.26383 Text en © 2022 The Author. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspective Nesci, Salvatore Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel |
title | Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel |
title_full | Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel |
title_fullStr | Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel |
title_full_unstemmed | Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel |
title_short | Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F(1)F(O)‐ATPase might open a high conductance ion channel |
title_sort | protein folding and unfolding: proline cis‐trans isomerization at the c subunits of f(1)f(o)‐atpase might open a high conductance ion channel |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790210/ https://www.ncbi.nlm.nih.gov/pubmed/35532281 http://dx.doi.org/10.1002/prot.26383 |
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