Cargando…

Calcium Channel α2δ1 is Essential for Pancreatic Tumor-Initiating Cells through Sequential Phosphorylation of PKM2

BACKGROUND & AIMS: Tumor-initiating cells (TICs) drive pancreatic cancer tumorigenesis, therapeutic resistance, and metastasis. However, TICs are highly plastic and heterogenous, which impede the robust identification and targeted therapy of such a population. The aim of this study is to identif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jingtao, Tao, Ming, Zhao, Wei, Song, Qingru, Yang, Xiaodan, Li, Meng, Zhang, Yanhua, Xiu, Dianrong, Zhang, Zhiqian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791133/ https://www.ncbi.nlm.nih.gov/pubmed/36244646 http://dx.doi.org/10.1016/j.jcmgh.2022.10.006

Ejemplares similares

Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer
por: Ma, Yuanyuan, et al.
Publicado: (2021)

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells
por: Jiang, Yuhui, et al.
Publicado: (2014)

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
por: Yang, Weiwei, et al.
Publicado: (2012)

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
por: Li, Tong, et al.
Publicado: (2019)

Voltage-dependent calcium channel α2δ1 subunit is a specific candidate marker for identifying gastric cancer stem cells
por: Zhang, Ziran, et al.
Publicado: (2019)

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the K(ATP) channel
por: Foster, Hannah R, et al.
Publicado: (2022)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

PolG Inhibits Gastric Cancer Glycolysis and Viability by Suppressing PKM2 Phosphorylation
por: Lv, Mengzhu, et al.
Publicado: (2021)

The α(2)δ Subunit and Absence Epilepsy: Beyond Calcium Channels?
por: Celli, Roberta, et al.
Publicado: (2017)

PKM2, function and expression and regulation
por: Zhang, Ze, et al.
Publicado: (2019)

Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α(2)δ-1 but not α(2)δ-3
por: Meyer, James O., et al.
Publicado: (2021)

AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth
por: Park, Young Soo, et al.
Publicado: (2016)

PKM2 in carcinogenesis and oncotherapy
por: He, Xia, et al.
Publicado: (2017)

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
por: Liang, Ji, et al.
Publicado: (2016)

Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity
por: Streets, Andrew J., et al.
Publicado: (2010)

Mechanisms of the gabapentinoids and α (2) δ‐1 calcium channel subunit in neuropathic pain
por: Patel, Ryan, et al.
Publicado: (2016)

Mirogabalin—A Novel Selective Ligand for the α2δ Calcium Channel Subunit
por: Zajączkowska, Renata, et al.
Publicado: (2021)

Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation
por: Zhang, Qiqi, et al.
Publicado: (2021)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization
por: Zhang, Mingzhi, et al.
Publicado: (2019)

Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development
por: Bikbaev, Arthur, et al.
Publicado: (2020)

Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition
por: Feng, Yanling, et al.
Publicado: (2018)

NEK2 Promotes Cell Proliferation and Glycolysis by Regulating PKM2 Abundance via Phosphorylation in Diffuse Large B-Cell Lymphoma
por: Zhou, Lingna, et al.
Publicado: (2021)

PKM2 is not required for colon cancer initiated by APC loss
por: Lau, Allison N., et al.
Publicado: (2017)

Correction to: PKM2, function and expression and regulation
por: Zhang, Ze, et al.
Publicado: (2019)

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma
por: Lakhter, Alexander J., et al.
Publicado: (2014)

Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation
por: Kang, Seo Young, et al.
Publicado: (2021)

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
por: Wu, Yinsheng, et al.
Publicado: (2023)

Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit α(2)δ-2 Mutant (Ducky) and α(2)δ Double Knockout Mice
por: Geisler, Stefanie M., et al.
Publicado: (2021)

Voltage-gated calcium channel α (2)δ subunits: an assessment of proposed novel roles
por: Dolphin, Annette C.
Publicado: (2018)

Inhibition of PKM2 Enhances Sensitivity of Olaparib to Ovarian Cancer Cells and Induces DNA Damage
por: Zhou, Sichun, et al.
Publicado: (2022)

Structural basis of PKM2 regulation
por: Yang, Weiwei
Publicado: (2015)

The Role of PKM2 in Diabetic Microangiopathy
por: Tu, Chao, et al.
Publicado: (2022)

PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC
por: Wang, Xiao, et al.
Publicado: (2020)

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
por: Yang, Weiwei, et al.
Publicado: (2011)

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
por: Bluemlein, Katharina, et al.
Publicado: (2011)

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis
por: Gai, Xiaochen, et al.
Publicado: (2022)

LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
por: Jia, Guizhi, et al.
Publicado: (2021)

PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment
por: Li, Tian-En, et al.
Publicado: (2020)

LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis
por: Pu, Feifei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tmod3fd7fchmhiaiulmuna4rom