Cargando…

Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer

BACKGROUND & AIMS: Approximately one-third of colorectal cancers develop from serrated lesions (SLs), including hyperplastic polyp (HP), sessile serrated lesion (SSL), traditional serrated adenoma (TSA), and SSL with dysplasia (SSLD) through the serrated neoplasia pathway, which progresses faste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yu-Jie, Lu, Xiao-Fan, Chen, Huimin, Wang, Xin-Yuan, Cheng, Wenxuan, Zhang, Qing-Wei, Chen, Jin-Nan, Wang, Xiao-Yi, Jin, Jing-Zheng, Yan, Fang-Rong, Chen, Haoyan, Li, Xiao-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791140/ https://www.ncbi.nlm.nih.gov/pubmed/36216310 http://dx.doi.org/10.1016/j.jcmgh.2022.10.001

Ejemplares similares

ERBB2 Mutations as Potential Predictors for Recurrence in Colorectal Serrated Polyps by Targeted Next-Generation Sequencing
por: Wang, Qi-Wen, et al.
Publicado: (2022)

5’tiRNA-Pro-TGG, a novel tRNA halve, promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer
por: Wang, Xin-Yuan, et al.
Publicado: (2023)

Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis
por: Kim, Soon Young, et al.
Publicado: (2018)

Different factors are associated with conventional adenoma and serrated colorectal neoplasia
por: Zorron Cheng Tao Pu, Leonardo, et al.
Publicado: (2020)

Polyps and Colorectal Cancer in Serrated Polyposis Syndrome: Contribution of the Classical Adenoma-Carcinoma and Serrated Neoplasia Pathways
por: van Toledo, David E. F. W. M., et al.
Publicado: (2023)

Coexistent adenoma and serrated polyps on index colonoscopy and the risk of metachronous advanced colorectal neoplasia
por: Park, Soo-Kyung, et al.
Publicado: (2019)

Large serrated polyps: molecular and familial links to a serrated neoplasia predisposition
por: Kalady, Matthew F, et al.
Publicado: (2010)

Incidental diagnosis of serrated polyp in the appendix warrants colonoscopy to screen for colorectal neoplasia
por: van Herwaarden, Y J, et al.
Publicado: (2021)

High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors
por: Rigter, Lisanne S., et al.
Publicado: (2018)

Increased Colorectal Neoplasia Risk in Patients with Inflammatory Bowel Disease and Serrated Polyps with Dysplasia
por: de Jong, Michiel E., et al.
Publicado: (2022)

Detection Rate, Distribution, Clinical and Pathological Features of Colorectal Serrated Polyps
por: Cao, Hai-Long, et al.
Publicado: (2016)

Serrated neoplasia in the colorectum: gut microbiota and molecular pathways
por: Kang, Xing, et al.
Publicado: (2020)

BRAF(V600E)-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism
por: Rzasa, Paulina, et al.
Publicado: (2023)

Low detection rate of advanced neoplasia within 5 years after polypectomy of small serrated adenoma
por: Jin, Duochen, et al.
Publicado: (2019)

Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme
por: McCarthy, A. J., et al.
Publicado: (2019)

Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions
por: Enomoto, Yuri, et al.
Publicado: (2023)

Notch signaling promotes serrated neoplasia pathway in colorectal cancer through epigenetic modification of EPHB2 and EPHB4
por: Lian, Haifeng, et al.
Publicado: (2018)

Functional characterization of the Arabidopsis SERRATE under salt stress
por: Mou, Minghui, et al.
Publicado: (2020)

CpG Island Methylator Phenotype-High Colorectal Cancers and Their Prognostic Implications and Relationships with the Serrated Neoplasia Pathway
por: Rhee, Ye-Young, et al.
Publicado: (2017)

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia
por: Bond, Catherine E., et al.
Publicado: (2018)

Usefulness of analyzing endoscopic features in identifying the colorectal serrated sessile lesions with and without dysplasia
por: Wang, Rui-Gang, et al.
Publicado: (2023)

Current progress on the endoscopic features of colorectal sessile serrated lesions
por: Wang, Rui-Gang, et al.
Publicado: (2023)

Long-Term Incidence of Advanced Colorectal Neoplasia in Patients with Serrated Polyposis Syndrome: Experience in a Single Academic Centre
por: Rodríguez-Alcalde, Daniel, et al.
Publicado: (2021)

Large serrated polyps indicate a greater risk of advanced metachronous colorectal neoplasia than high-grade adenomas
por: Medawar, Edgard, et al.
Publicado: (2023)

Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma
por: Kawasaki, Takako, et al.
Publicado: (2008)

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis
por: Bond, Catherine E., et al.
Publicado: (2016)

Genetics of the Serrated Pathway to Colorectal Cancer
por: Kedrin, Dmitriy, et al.
Publicado: (2015)

Flat Serrated Adenomas of the Colorectal Mucosa
por: Rubio, Carlos A., et al.
Publicado: (1996)

Colorectal Adenocarcinoma with an Alternative Serrated Pathway
por: Eizuka, Makoto, et al.
Publicado: (2018)

The clinical impact of serrated colorectal polyps
por: O’Connell, Brendon M, et al.
Publicado: (2017)

Risk factors for recurrence of colorectal conventional adenoma and serrated polyp
por: Chi, Zengjie, et al.
Publicado: (2021)

Characteristics and outcomes of endoscopically resected colorectal cancers that arose from sessile serrated adenomas and traditional serrated adenomas
por: Seo, Ji Yeon, et al.
Publicado: (2016)

The prevalence of sessile serrated lesion in the colorectum and its relationship to synchronous colorectal advanced neoplasia: a systemic review and meta-analysis
por: Shiu, Sz-Iuan, et al.
Publicado: (2021)

Linkage to chromosome 2q32.2-q35 in families with serrated neoplasia
por: Roberts, Aedan, et al.
Publicado: (2010)

Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival
por: Lee, Chung-Ta, et al.
Publicado: (2017)

Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: a multicenter study
por: Wu, Xian-Rui, et al.
Publicado: (2019)

Prevalence of Different Subtypes of Serrated Polyps and Risk of Synchronous Advanced Colorectal Neoplasia in Average-Risk Population Undergoing First-Time Colonoscopy
por: Buda, Andrea, et al.
Publicado: (2012)

Role of Fusobacteria in the serrated pathway of colorectal carcinogenesis
por: Park, Chan Hyuk, et al.
Publicado: (2016)

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer
por: De Palma, Fatima Domenica Elisa, et al.
Publicado: (2019)

An “expressionistic” look at serrated precancerous colorectal lesions
por: Marra, Giancarlo
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r2g9f169q5l4vqqmmav73l4u37