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Meeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing
Integrating vectors are associated with alterations in cellular function related to disruption of normal gene function. This has been associated with clonal expansion of cells and, in some instances, cancer. These events have been associated with replication-defective vectors and suggest that the in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791246/ https://www.ncbi.nlm.nih.gov/pubmed/36588821 http://dx.doi.org/10.1016/j.omtm.2022.11.009 |