TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis

BACKGROUND: Leukemia-associated macrophages (LAMs) represent an important cell population within the tumor microenvironment, but little is known about the phenotype, function, and plasticity of these cells. The present study provides an extensive characterization of macrophages in patients with acut...

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Detalles Bibliográficos
Autores principales: Brauneck, Franziska, Fischer, Brit, Witt, Marius, Muschhammer, Jana, Oelrich, Jennyfer, da Costa Avelar, Pedro Henrique, Tsoka, Sophia, Bullinger, Lars, Seubert, Elisa, Smit, Daniel J, Bokemeyer, Carsten, Ackermann, Christin, Wellbrock, Jasmin, Haag, Friedrich, Fiedler, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791419/
https://www.ncbi.nlm.nih.gov/pubmed/36549780
http://dx.doi.org/10.1136/jitc-2022-004794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791419/
https://www.ncbi.nlm.nih.gov/pubmed/36549780
http://dx.doi.org/10.1136/jitc-2022-004794

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