Cargando…
Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project
INTRODUCTION: Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791453/ https://www.ncbi.nlm.nih.gov/pubmed/36564114 http://dx.doi.org/10.1136/bmjopen-2022-063903 |
_version_ | 1784859410209701888 |
---|---|
author | Gibbons, Catherine O'Hara, Beverley O’Connor, Dominic Hardman, Charlotte Wilton, Moon Harrold, Joanne A Almiron-Roig, Eva Navas-Carretero, Santiago Hodgkins, Charo E Nazare, Julie Anne Alligier, Maud Martínez, Jose Alfredo Scott, Corey Kjølbæk, Louise Normand, Mie Rannou, Cécile Blaak, Ellen E Feskens, Edith Moshoyiannis, Hariklia Raben, Anne Halford, Jason C G Beaulieu, Kristine Finlayson, Graham |
author_facet | Gibbons, Catherine O'Hara, Beverley O’Connor, Dominic Hardman, Charlotte Wilton, Moon Harrold, Joanne A Almiron-Roig, Eva Navas-Carretero, Santiago Hodgkins, Charo E Nazare, Julie Anne Alligier, Maud Martínez, Jose Alfredo Scott, Corey Kjølbæk, Louise Normand, Mie Rannou, Cécile Blaak, Ellen E Feskens, Edith Moshoyiannis, Hariklia Raben, Anne Halford, Jason C G Beaulieu, Kristine Finlayson, Graham |
author_sort | Gibbons, Catherine |
collection | PubMed |
description | INTRODUCTION: Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. METHODS AND ANALYSIS: A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25–35 kg/m(2); aged 18–60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14. ETHICS AND DISSEMINATION: The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive. TRIAL REGISTRATION NUMBER: NCT04633681. |
format | Online Article Text |
id | pubmed-9791453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-97914532022-12-27 Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project Gibbons, Catherine O'Hara, Beverley O’Connor, Dominic Hardman, Charlotte Wilton, Moon Harrold, Joanne A Almiron-Roig, Eva Navas-Carretero, Santiago Hodgkins, Charo E Nazare, Julie Anne Alligier, Maud Martínez, Jose Alfredo Scott, Corey Kjølbæk, Louise Normand, Mie Rannou, Cécile Blaak, Ellen E Feskens, Edith Moshoyiannis, Hariklia Raben, Anne Halford, Jason C G Beaulieu, Kristine Finlayson, Graham BMJ Open Nutrition and Metabolism INTRODUCTION: Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. METHODS AND ANALYSIS: A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25–35 kg/m(2); aged 18–60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14. ETHICS AND DISSEMINATION: The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive. TRIAL REGISTRATION NUMBER: NCT04633681. BMJ Publishing Group 2022-12-23 /pmc/articles/PMC9791453/ /pubmed/36564114 http://dx.doi.org/10.1136/bmjopen-2022-063903 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Nutrition and Metabolism Gibbons, Catherine O'Hara, Beverley O’Connor, Dominic Hardman, Charlotte Wilton, Moon Harrold, Joanne A Almiron-Roig, Eva Navas-Carretero, Santiago Hodgkins, Charo E Nazare, Julie Anne Alligier, Maud Martínez, Jose Alfredo Scott, Corey Kjølbæk, Louise Normand, Mie Rannou, Cécile Blaak, Ellen E Feskens, Edith Moshoyiannis, Hariklia Raben, Anne Halford, Jason C G Beaulieu, Kristine Finlayson, Graham Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project |
title | Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project |
title_full | Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project |
title_fullStr | Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project |
title_full_unstemmed | Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project |
title_short | Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project |
title_sort | acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, rct in people with overweight/obesity – the sweet project |
topic | Nutrition and Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791453/ https://www.ncbi.nlm.nih.gov/pubmed/36564114 http://dx.doi.org/10.1136/bmjopen-2022-063903 |
work_keys_str_mv | AT gibbonscatherine acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT oharabeverley acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT oconnordominic acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT hardmancharlotte acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT wiltonmoon acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT harroldjoannea acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT almironroigeva acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT navascarreterosantiago acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT hodgkinscharoe acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT nazarejulieanne acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT alligiermaud acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT martinezjosealfredo acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT scottcorey acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT kjølbæklouise acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT normandmie acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT rannoucecile acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT blaakellene acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT feskensedith acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT moshoyiannishariklia acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT rabenanne acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT halfordjasoncg acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT beaulieukristine acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject AT finlaysongraham acuteandrepeatedimpactofsweetenersandsweetnessenhancersinsolidandsemisolidfoodsonappetiteprotocolforamulticentrecrossoverrctinpeoplewithoverweightobesitythesweetproject |