Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

OBJECTIVE: Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription factor P53 (also known as TP53 and Trp53 in mic...

Descripción completa

Detalles Bibliográficos
Autores principales: Uhlemeyer, Celina, Müller, Nadine, Rieck, Michael, Kuboth, Jennifer, Schlegel, Caroline, Grieß, Kerstin, Dorweiler, Tim Florian, Heiduschka, Sonja, Eckel, Jürgen, Roden, Michael, Lammert, Eckhard, Stoffel, Markus, Belgardt, Bengt-Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791454/
https://www.ncbi.nlm.nih.gov/pubmed/36470401
http://dx.doi.org/10.1016/j.molmet.2022.101650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791454/
https://www.ncbi.nlm.nih.gov/pubmed/36470401
http://dx.doi.org/10.1016/j.molmet.2022.101650

Ejemplares similares