Transition of amyloid/mutant p53 from tumor suppressor to an oncogene and therapeutic approaches to ameliorate metastasis and cancer stemness

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-function (GOF) activities that affect molecular pathways crucial for tumorigenesis and progression like some of the p53 mutants. Even after successful cancer treatment, metastasis and recurrence can result in poor surv...

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Detalles Bibliográficos
Autores principales: Sengupta, Shinjinee, Ghufran, Shaikh Maryam, Khan, Aqsa, Biswas, Subhrajit, Roychoudhury, Susanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791775/
https://www.ncbi.nlm.nih.gov/pubmed/36567312
http://dx.doi.org/10.1186/s12935-022-02831-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791775/
https://www.ncbi.nlm.nih.gov/pubmed/36567312
http://dx.doi.org/10.1186/s12935-022-02831-4

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