Cargando…

Transition of amyloid/mutant p53 from tumor suppressor to an oncogene and therapeutic approaches to ameliorate metastasis and cancer stemness

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-function (GOF) activities that affect molecular pathways crucial for tumorigenesis and progression like some of the p53 mutants. Even after successful cancer treatment, metastasis and recurrence can result in poor surv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sengupta, Shinjinee, Ghufran, Shaikh Maryam, Khan, Aqsa, Biswas, Subhrajit, Roychoudhury, Susanta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791775/ https://www.ncbi.nlm.nih.gov/pubmed/36567312 http://dx.doi.org/10.1186/s12935-022-02831-4

Ejemplares similares

Transcriptome wide functional analysis of HBx expressing human hepatocytes stimulated with endothelial cell cross-talk
por: Ghufran, Shaikh Maryam, et al.
Publicado: (2023)

Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells
por: Sharma, Sachin, et al.
Publicado: (2021)

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers
por: Pedrote, Murilo M., et al.
Publicado: (2020)

Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants
por: Yang, Lu, et al.
Publicado: (2021)

Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53
por: Datta, Arindam, et al.
Publicado: (2016)

Targeting Oncogenic Mutant p53 for Cancer Therapy
por: Parrales, Alejandro, et al.
Publicado: (2015)

Regulators of Oncogenic Mutant TP53 Gain of Function
por: Yamamoto, Satomi, et al.
Publicado: (2018)

Cancer Stemness: p53 at the Wheel
por: Ghatak, Dishari, et al.
Publicado: (2021)

Plakoglobin restores tumor suppressor activity of p53(R175H) mutant by sequestering the oncogenic potential of β‐catenin
por: Alaee, Mahsa, et al.
Publicado: (2018)

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
por: Palanikumar, L., et al.
Publicado: (2021)

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1
por: Tian, Shuye, et al.
Publicado: (2017)

The Contrived Mutant p53 Oncogene – Beyond Loss of Functions
por: Sabapathy, Kanaga
Publicado: (2015)

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53
por: Napoli, Marco, et al.
Publicado: (2011)

The rebel angel: mutant p53 as the driving oncogene in breast cancer
por: Walerych, Dawid, et al.
Publicado: (2012)

Corrigendum: The Contrived Mutant p53 Oncogene – Beyond Loss of Functions
por: Sabapathy, Kanaga
Publicado: (2021)

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
por: Banerjee, Taraswi, et al.
Publicado: (2009)

Genome-Wide Small RNA Sequencing Identifies MicroRNAs Deregulated in Non-Small Cell Lung Carcinoma Harboring Gain-of-Function Mutant p53
por: Datta, Arindam, et al.
Publicado: (2019)

Z-Guggulsterone Is a Potential Lead Molecule of Dawa-ul-Kurkum against Hepatocellular Carcinoma
por: Gupta, Meenakshi, et al.
Publicado: (2022)

In Silico Strategies for Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant: Inhibiting Cancer Growth and Proliferation
por: Ghufran, Mehreen, et al.
Publicado: (2022)

Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism
por: Zhou, Ge, et al.
Publicado: (2014)

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
por: Kadosh, Eliran, et al.
Publicado: (2020)

Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors
por: Li, Hui, et al.
Publicado: (2019)

Amplifying Tumor–Stroma Communication: An Emerging Oncogenic Function of Mutant p53
por: Capaci, Valeria, et al.
Publicado: (2021)

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
por: Vaughan, Catherine A., et al.
Publicado: (2021)

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation
por: Aylon, Yael, et al.
Publicado: (2009)

Tumor-Suppressor Genes and Oncogenes
Publicado: (1993)

Oncogenes and tumor-suppressor genes.
por: Lehman, T A, et al.
Publicado: (1991)

Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
por: Kaypee, Stephanie, et al.
Publicado: (2018)

Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma
por: Kancherla, Venkatesh, et al.
Publicado: (2018)

Control of Nucleotide Metabolism Enables Mutant p53’s Oncogenic Gain-of-Function Activity
por: Schmidt, Valentina, et al.
Publicado: (2017)

Bioinformatic Analysis of Circadian Expression of Oncogenes and Tumor Suppressor Genes
por: Salavaty, Abbas, et al.
Publicado: (2017)

Mutant p53 regulates Survivin to foster lung metastasis
por: Tang, Qiaosi, et al.
Publicado: (2021)

RUNX family: Oncogenes or tumor suppressors
por: Otálora-Otálora, Beatriz Andrea, et al.
Publicado: (2019)

Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers
por: Morrison, Chevaun D, et al.
Publicado: (2017)

The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells
por: Butera, Giovanna, et al.
Publicado: (2020)

Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment
por: Neely, Victoria, et al.
Publicado: (2023)

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: IMPLICATIONS FOR CANCER
por: Ano Bom, Ana P. D., et al.
Publicado: (2012)

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
por: Coppé, Jean-Philippe, et al.
Publicado: (2008)

Inhibition of Breast Cancer Metastasis Suppressor 1 Promotes a Mesenchymal Phenotype in Lung Epithelial Cells That Express Oncogenic K-Ras(V12) and Loss of p53
por: Hall, Emily H., et al.
Publicado: (2014)

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant
por: Slatter, T L, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5t49bhvtcs8fg7tjmne556fk01