Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

Crosstalk between metabolic and signaling events that induce tumor metastasis remains elusive. Here, we determine how oncogenic sphingosine 1-phosphate (S1P) metabolism induces intracellular C3 complement activation to enhance migration/metastasis. We demonstrate that increased S1P metabolism activa...

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Detalles Bibliográficos
Autores principales: Janneh, Alhaji H., Kassir, Mohamed Faisal, Atilgan, F. Cansu, Lee, Han Gyul, Sheridan, Megan, Oleinik, Natalia, Szulc, Zdzislaw, Voelkel-Johnson, Christina, Nguyen, Hung, Li, Hong, Peterson, Yuri K., Marangoni, Elisabetta, Saatci, Ozge, Sahin, Ozgur, Lilly, Michael, Atkinson, Carl, Tomlinson, Stephen, Mehrotra, Shikhar, Ogretmen, Besim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791981/
https://www.ncbi.nlm.nih.gov/pubmed/36476873
http://dx.doi.org/10.1016/j.celrep.2022.111742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791981/
https://www.ncbi.nlm.nih.gov/pubmed/36476873
http://dx.doi.org/10.1016/j.celrep.2022.111742

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