Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAF(V600E)

Thiourea derivatives of uracil were efficiently synthesized via the reaction of 5-aminouracil with isothiocyanates. Then, we prepared uracil-containing thiazoles via condensation of thioureas with diethyl/dimethyl acetylenedicarboxylates. The structures of the products were confirmed by a combinatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Alshammari, Mohammed B., Aly, Ashraf A., Youssif, Bahaa G. M., Bräse, Stefan, Ahmad, Akil, Brown, Alan B., Ibrahim, Mahmoud A. A., Mohamed, Asmaa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792171/
https://www.ncbi.nlm.nih.gov/pubmed/36578355
http://dx.doi.org/10.3389/fchem.2022.1076383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792171/
https://www.ncbi.nlm.nih.gov/pubmed/36578355
http://dx.doi.org/10.3389/fchem.2022.1076383

Ejemplares similares