Downregulation of Sirt6 by CD38 promotes cell senescence and aging

Decreased nicotinamide adenine dinucleotide (NAD+) levels accompany aging. CD38 is the main cellular NADase. Cyanidin-3-O-glucoside (C3G), a natural inhibitor of CD38, is a well-known drug that extends the human lifespan. We investigated mechanisms of CD38 in cell senescence and C3G in antiaging. My...

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Detalles Bibliográficos
Autores principales: Zhou, Hongji, Liu, Shihai, Zhang, NanYang, Fang, Kehua, Zong, Jinbao, An, Yi, Chang, Xiaotian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792202/
https://www.ncbi.nlm.nih.gov/pubmed/36490326
http://dx.doi.org/10.18632/aging.204425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792202/
https://www.ncbi.nlm.nih.gov/pubmed/36490326
http://dx.doi.org/10.18632/aging.204425

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