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Research Progress of Population Pharmacokinetic of Metformin
Metformin is commonly used as first-line treatment for T2DM (type2 diabetes mellitus). Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic (PPK) models have been developed for metformin to explore potential covariates that affect its pharmacokinetic variation. This...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792241/ https://www.ncbi.nlm.nih.gov/pubmed/36578804 http://dx.doi.org/10.1155/2022/4071111 |
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author | Wang, Xiaohu Tang, Jin Shen, Chaozhuang Wang, Xingwen Hu, Hua Xie, Haitang |
author_facet | Wang, Xiaohu Tang, Jin Shen, Chaozhuang Wang, Xingwen Hu, Hua Xie, Haitang |
author_sort | Wang, Xiaohu |
collection | PubMed |
description | Metformin is commonly used as first-line treatment for T2DM (type2 diabetes mellitus). Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic (PPK) models have been developed for metformin to explore potential covariates that affect its pharmacokinetic variation. This comprehensive review summarized the published PPK studies of metformin, aimed to summarize PPK models of metformin. Most studies described metformin pharmacokinetics as a 2-compartment (2-CMT) model with 4 study describing its pharmacokinetics as 1-compartment (1-CMT). Studies on metformin PPK have shown that obesity, creatinine clearance (CL(Cr)), gene polymorphism, degree of renal function damage, and pathological conditions all have a certain impact on the PK parameters of metformin. It is particularly important to formulate individualized dosing regimens. For future PPK studies of metformin, we believe that more attention should be paid to special populations. |
format | Online Article Text |
id | pubmed-9792241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-97922412022-12-27 Research Progress of Population Pharmacokinetic of Metformin Wang, Xiaohu Tang, Jin Shen, Chaozhuang Wang, Xingwen Hu, Hua Xie, Haitang Biomed Res Int Review Article Metformin is commonly used as first-line treatment for T2DM (type2 diabetes mellitus). Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic (PPK) models have been developed for metformin to explore potential covariates that affect its pharmacokinetic variation. This comprehensive review summarized the published PPK studies of metformin, aimed to summarize PPK models of metformin. Most studies described metformin pharmacokinetics as a 2-compartment (2-CMT) model with 4 study describing its pharmacokinetics as 1-compartment (1-CMT). Studies on metformin PPK have shown that obesity, creatinine clearance (CL(Cr)), gene polymorphism, degree of renal function damage, and pathological conditions all have a certain impact on the PK parameters of metformin. It is particularly important to formulate individualized dosing regimens. For future PPK studies of metformin, we believe that more attention should be paid to special populations. Hindawi 2022-12-19 /pmc/articles/PMC9792241/ /pubmed/36578804 http://dx.doi.org/10.1155/2022/4071111 Text en Copyright © 2022 Xiaohu Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Xiaohu Tang, Jin Shen, Chaozhuang Wang, Xingwen Hu, Hua Xie, Haitang Research Progress of Population Pharmacokinetic of Metformin |
title | Research Progress of Population Pharmacokinetic of Metformin |
title_full | Research Progress of Population Pharmacokinetic of Metformin |
title_fullStr | Research Progress of Population Pharmacokinetic of Metformin |
title_full_unstemmed | Research Progress of Population Pharmacokinetic of Metformin |
title_short | Research Progress of Population Pharmacokinetic of Metformin |
title_sort | research progress of population pharmacokinetic of metformin |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792241/ https://www.ncbi.nlm.nih.gov/pubmed/36578804 http://dx.doi.org/10.1155/2022/4071111 |
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