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Research Progress of Population Pharmacokinetic of Metformin

Metformin is commonly used as first-line treatment for T2DM (type2 diabetes mellitus). Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic (PPK) models have been developed for metformin to explore potential covariates that affect its pharmacokinetic variation. This...

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Autores principales: Wang, Xiaohu, Tang, Jin, Shen, Chaozhuang, Wang, Xingwen, Hu, Hua, Xie, Haitang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792241/
https://www.ncbi.nlm.nih.gov/pubmed/36578804
http://dx.doi.org/10.1155/2022/4071111
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author Wang, Xiaohu
Tang, Jin
Shen, Chaozhuang
Wang, Xingwen
Hu, Hua
Xie, Haitang
author_facet Wang, Xiaohu
Tang, Jin
Shen, Chaozhuang
Wang, Xingwen
Hu, Hua
Xie, Haitang
author_sort Wang, Xiaohu
collection PubMed
description Metformin is commonly used as first-line treatment for T2DM (type2 diabetes mellitus). Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic (PPK) models have been developed for metformin to explore potential covariates that affect its pharmacokinetic variation. This comprehensive review summarized the published PPK studies of metformin, aimed to summarize PPK models of metformin. Most studies described metformin pharmacokinetics as a 2-compartment (2-CMT) model with 4 study describing its pharmacokinetics as 1-compartment (1-CMT). Studies on metformin PPK have shown that obesity, creatinine clearance (CL(Cr)), gene polymorphism, degree of renal function damage, and pathological conditions all have a certain impact on the PK parameters of metformin. It is particularly important to formulate individualized dosing regimens. For future PPK studies of metformin, we believe that more attention should be paid to special populations.
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spelling pubmed-97922412022-12-27 Research Progress of Population Pharmacokinetic of Metformin Wang, Xiaohu Tang, Jin Shen, Chaozhuang Wang, Xingwen Hu, Hua Xie, Haitang Biomed Res Int Review Article Metformin is commonly used as first-line treatment for T2DM (type2 diabetes mellitus). Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic (PPK) models have been developed for metformin to explore potential covariates that affect its pharmacokinetic variation. This comprehensive review summarized the published PPK studies of metformin, aimed to summarize PPK models of metformin. Most studies described metformin pharmacokinetics as a 2-compartment (2-CMT) model with 4 study describing its pharmacokinetics as 1-compartment (1-CMT). Studies on metformin PPK have shown that obesity, creatinine clearance (CL(Cr)), gene polymorphism, degree of renal function damage, and pathological conditions all have a certain impact on the PK parameters of metformin. It is particularly important to formulate individualized dosing regimens. For future PPK studies of metformin, we believe that more attention should be paid to special populations. Hindawi 2022-12-19 /pmc/articles/PMC9792241/ /pubmed/36578804 http://dx.doi.org/10.1155/2022/4071111 Text en Copyright © 2022 Xiaohu Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Xiaohu
Tang, Jin
Shen, Chaozhuang
Wang, Xingwen
Hu, Hua
Xie, Haitang
Research Progress of Population Pharmacokinetic of Metformin
title Research Progress of Population Pharmacokinetic of Metformin
title_full Research Progress of Population Pharmacokinetic of Metformin
title_fullStr Research Progress of Population Pharmacokinetic of Metformin
title_full_unstemmed Research Progress of Population Pharmacokinetic of Metformin
title_short Research Progress of Population Pharmacokinetic of Metformin
title_sort research progress of population pharmacokinetic of metformin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792241/
https://www.ncbi.nlm.nih.gov/pubmed/36578804
http://dx.doi.org/10.1155/2022/4071111
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