Haptoglobin 1 allele predicts higher serum haptoglobin concentration and lower multiorgan failure risk in sickle cell disease

Haptoglobin (HP) is an acute-phase protein and the main scavenger of cell-free hemoglobin. When HP is depleted, as observed in hemolytic conditions such as sickle cell disease (SCD), cell-free hemoglobin can lead to acute organ damage. The impact of the HP 1-1, 2-1, and 2-2 isoforms on HP and cell-f...

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Detalles Bibliográficos
Autores principales: Ruiz, Maria A., Shah, Binal N., Ren, Guohui, Hussain, Faiz, Njoku, Franklin, Machado, Roberto F., Gordeuk, Victor R., Saraf, Santosh L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792396/
https://www.ncbi.nlm.nih.gov/pubmed/36006620
http://dx.doi.org/10.1182/bloodadvances.2022007980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792396/
https://www.ncbi.nlm.nih.gov/pubmed/36006620
http://dx.doi.org/10.1182/bloodadvances.2022007980

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