Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells

cGAS/STING axis is the major executor of cytosolic dsDNA sensing that leads to the production of type I interferon (IFNI) not only upon bacterial infection, but also in cancer cells, upon DNA damage. In fact, DNA damage caused by ionizing radiations and/or topoisomerase inhibitors leads to a release...

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Detalles Bibliográficos
Autores principales: Occhigrossi, Luca, D’Eletto, Manuela, Vecchio, Alessio, Piacentini, Mauro, Rossin, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792452/
https://www.ncbi.nlm.nih.gov/pubmed/36572679
http://dx.doi.org/10.1038/s41420-022-01278-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792452/
https://www.ncbi.nlm.nih.gov/pubmed/36572679
http://dx.doi.org/10.1038/s41420-022-01278-w

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