Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy

The failing heart is characterized by an increase in glucose uptake and glycolytic rates that is not accompanied by a concomitant increase in glucose oxidation. Lower coupling of glucose oxidation to glycolysis possibly owes to unchanged or reduced pyruvate oxidation in mitochondria. Therefore, incr...

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Detalles Bibliográficos
Autores principales: Ni, Jingyu, Zhang, Hao, Wang, Xiaodan, Liu, Zhihao, Nie, Tong, Li, Lan, Su, Jing, Zhu, Yan, Ma, Chuanrui, Huang, Yuting, Mao, Jingyuan, Gao, Xiumei, Fan, Guanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792576/
https://www.ncbi.nlm.nih.gov/pubmed/36572672
http://dx.doi.org/10.1038/s41419-022-05516-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792576/
https://www.ncbi.nlm.nih.gov/pubmed/36572672
http://dx.doi.org/10.1038/s41419-022-05516-y

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