Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo

Colchicine is a bioactive alkaloid originally from Colchicum autumnale and possesses excellent antiproliferative activity. However, colchicine-associated severe toxicity, gastrointestinal side effects in particular, limits its further therapeutic use. In the current study, we thus designed and synth...

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Detalles Bibliográficos
Autores principales: Li, Zhiyue, Hu, Shengquan, Pu, Liu-Yang, Li, Ziwen, Zhu, Guanbao, Cao, Yongkai, Li, Limin, Ma, Yucui, Liu, Zhanyan, Li, Xinping, Liu, Guangjie, Chen, Keji, Wu, Zhengzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792613/
https://www.ncbi.nlm.nih.gov/pubmed/36583151
http://dx.doi.org/10.3389/fchem.2022.1094019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792613/
https://www.ncbi.nlm.nih.gov/pubmed/36583151
http://dx.doi.org/10.3389/fchem.2022.1094019

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