Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases

IMP-type metallo-β-lactamases confer resistance to carbapenems and a broad spectrum of β-lactam antibiotics. IMP-6 and IMP-1 differ by only a point mutation: Ser262 in IMP-1 and Gly262 in IMP-6. The k(cat)/K(m) values of IMP-1 for imipenem and meropenem are nearly identical; however, for IMP-6, the...

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Detalles Bibliográficos
Autores principales: Yamamoto, Keizo, Tanaka, Hideaki, Kurisu, Genji, Nakano, Ryuichi, Yano, Hisakazu, Sakai, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Regular Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792659/
https://www.ncbi.nlm.nih.gov/pubmed/36174533
http://dx.doi.org/10.1093/jb/mvac080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792659/
https://www.ncbi.nlm.nih.gov/pubmed/36174533
http://dx.doi.org/10.1093/jb/mvac080

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