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Benefits of dietary polyphenols in Alzheimer’s disease

Alzheimer′s disease (AD) is an irreversible progressive neurodegenerative disease affecting approximately 50 million people worldwide. It is estimated to reach 152 million by the year 2050. AD is the fifth leading cause of death among Americans age 65 and older. In spite of the significant burden th...

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Autores principales: El Gaamouch, Farida, Chen, Fiona, Ho, Lap, Lin, Hsiao-Yun, Yuan, Chongzhen, Wong, Jean, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792677/
https://www.ncbi.nlm.nih.gov/pubmed/36583187
http://dx.doi.org/10.3389/fnagi.2022.1019942
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author El Gaamouch, Farida
Chen, Fiona
Ho, Lap
Lin, Hsiao-Yun
Yuan, Chongzhen
Wong, Jean
Wang, Jun
author_facet El Gaamouch, Farida
Chen, Fiona
Ho, Lap
Lin, Hsiao-Yun
Yuan, Chongzhen
Wong, Jean
Wang, Jun
author_sort El Gaamouch, Farida
collection PubMed
description Alzheimer′s disease (AD) is an irreversible progressive neurodegenerative disease affecting approximately 50 million people worldwide. It is estimated to reach 152 million by the year 2050. AD is the fifth leading cause of death among Americans age 65 and older. In spite of the significant burden the disease imposes upon patients, their families, our society, and our healthcare system, there is currently no cure for AD. The existing approved therapies only temporarily alleviate some of the disease’s symptoms, but are unable to modulate the onset and/or progression of the disease. Our failure in developing a cure for AD is attributable, in part, to the multifactorial complexity underlying AD pathophysiology. Nonetheless, the lack of successful pharmacological approaches has led to the consideration of alternative strategies that may help delay the onset and progression of AD. There is increasing recognition that certain dietary and nutrition factors may play important roles in protecting against select key AD pathologies. Consistent with this, select nutraceuticals and phytochemical compounds have demonstrated anti-amyloidogenic, antioxidative, anti-inflammatory, and neurotrophic properties and as such, could serve as lead candidates for further novel AD therapeutic developments. Here we summarize some of the more promising dietary phytochemicals, particularly polyphenols that have been shown to positively modulate some of the important AD pathogenesis aspects, such as reducing β-amyloid plaques and neurofibrillary tangles formation, AD-induced oxidative stress, neuroinflammation, and synapse loss. We also discuss the recent development of potential contribution of gut microbiome in dietary polyphenol function.
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spelling pubmed-97926772022-12-28 Benefits of dietary polyphenols in Alzheimer’s disease El Gaamouch, Farida Chen, Fiona Ho, Lap Lin, Hsiao-Yun Yuan, Chongzhen Wong, Jean Wang, Jun Front Aging Neurosci Aging Neuroscience Alzheimer′s disease (AD) is an irreversible progressive neurodegenerative disease affecting approximately 50 million people worldwide. It is estimated to reach 152 million by the year 2050. AD is the fifth leading cause of death among Americans age 65 and older. In spite of the significant burden the disease imposes upon patients, their families, our society, and our healthcare system, there is currently no cure for AD. The existing approved therapies only temporarily alleviate some of the disease’s symptoms, but are unable to modulate the onset and/or progression of the disease. Our failure in developing a cure for AD is attributable, in part, to the multifactorial complexity underlying AD pathophysiology. Nonetheless, the lack of successful pharmacological approaches has led to the consideration of alternative strategies that may help delay the onset and progression of AD. There is increasing recognition that certain dietary and nutrition factors may play important roles in protecting against select key AD pathologies. Consistent with this, select nutraceuticals and phytochemical compounds have demonstrated anti-amyloidogenic, antioxidative, anti-inflammatory, and neurotrophic properties and as such, could serve as lead candidates for further novel AD therapeutic developments. Here we summarize some of the more promising dietary phytochemicals, particularly polyphenols that have been shown to positively modulate some of the important AD pathogenesis aspects, such as reducing β-amyloid plaques and neurofibrillary tangles formation, AD-induced oxidative stress, neuroinflammation, and synapse loss. We also discuss the recent development of potential contribution of gut microbiome in dietary polyphenol function. Frontiers Media S.A. 2022-12-13 /pmc/articles/PMC9792677/ /pubmed/36583187 http://dx.doi.org/10.3389/fnagi.2022.1019942 Text en Copyright © 2022 El Gaamouch, Chen, Ho, Lin, Yuan, Wong and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
El Gaamouch, Farida
Chen, Fiona
Ho, Lap
Lin, Hsiao-Yun
Yuan, Chongzhen
Wong, Jean
Wang, Jun
Benefits of dietary polyphenols in Alzheimer’s disease
title Benefits of dietary polyphenols in Alzheimer’s disease
title_full Benefits of dietary polyphenols in Alzheimer’s disease
title_fullStr Benefits of dietary polyphenols in Alzheimer’s disease
title_full_unstemmed Benefits of dietary polyphenols in Alzheimer’s disease
title_short Benefits of dietary polyphenols in Alzheimer’s disease
title_sort benefits of dietary polyphenols in alzheimer’s disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792677/
https://www.ncbi.nlm.nih.gov/pubmed/36583187
http://dx.doi.org/10.3389/fnagi.2022.1019942
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