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Resistance mechanisms in BRAF(V600E) paediatric high-grade glioma and current therapeutic approaches
Paediatric high-grade gliomas (pHGG) are aggressive central nervous system tumours with a poor prognosis. BRAF(V600E) mutant pHGGs can be treated with targeted BRAF inhibitors, which have shown both preclinical activity and potent clinical efficacy. Unfortunately, the development of drug resistance...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792688/ https://www.ncbi.nlm.nih.gov/pubmed/36582791 http://dx.doi.org/10.3389/fonc.2022.1031378 |