Developmental cues license megakaryocyte priming in murine hematopoietic stem cells

The fetal-to-adult switch in hematopoietic stem cell (HSC) behavior is characterized by alterations in lineage output and entry into deep quiescence. Here we identify the emergence of megakaryocyte (Mk)-biased HSCs as an event coinciding with this developmental switch. Single-cell chromatin accessib...

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Detalles Bibliográficos
Autores principales: Kristiansen, Trine A., Zhang, Qinyu, Vergani, Stefano, Boldrin, Elena, Krausse, Niklas, André, Oscar, Nordenfelt, Pontus, Sigvardsson, Mikael, Bryder, David, Ungerbäck, Jonas, Yuan, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792704/
https://www.ncbi.nlm.nih.gov/pubmed/35584393
http://dx.doi.org/10.1182/bloodadvances.2021006861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792704/
https://www.ncbi.nlm.nih.gov/pubmed/35584393
http://dx.doi.org/10.1182/bloodadvances.2021006861

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