Scavenging dicarbonyls with 5′-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

OBJECTIVE: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellular proteins, phospholipids, and DNA leading to a...

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Detalles Bibliográficos
Autores principales: Huang, Jiansheng, Tao, Huan, Yancey, Patricia G., Leuthner, Zoe, May-Zhang, Linda S., Jung, Ju-Yang, Zhang, Youmin, Ding, Lei, Amarnath, Venkataraman, Liu, Dianxin, Collins, Sheila, Davies, Sean S., Linton, MacRae F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792904/
https://www.ncbi.nlm.nih.gov/pubmed/36481344
http://dx.doi.org/10.1016/j.molmet.2022.101651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792904/
https://www.ncbi.nlm.nih.gov/pubmed/36481344
http://dx.doi.org/10.1016/j.molmet.2022.101651

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