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Negative cooperativity underlies dynamic assembly of the Par complex regulators Cdc42 and Par-3
The Par complex polarizes diverse animal cells through the concerted action of multiple regulators. Binding to the multi-PDZ domain containing protein Par-3 couples the complex to cortical flows that construct the Par membrane domain. Once localized properly, the complex is thought to transition fro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793311/ https://www.ncbi.nlm.nih.gov/pubmed/36436559 http://dx.doi.org/10.1016/j.jbc.2022.102749 |