TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43, which are detected in nearly all patients. Mutations in the gene that encodes TDP-43 (TARBDP) are known to result in both fam...

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Detalles Bibliográficos
Autores principales: Lépine, Sarah, Castellanos-Montiel, Maria José, Durcan, Thomas Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793560/
https://www.ncbi.nlm.nih.gov/pubmed/36575535
http://dx.doi.org/10.1186/s40035-022-00331-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793560/
https://www.ncbi.nlm.nih.gov/pubmed/36575535
http://dx.doi.org/10.1186/s40035-022-00331-z

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