Cargando…
TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43, which are detected in nearly all patients. Mutations in the gene that encodes TDP-43 (TARBDP) are known to result in both fam...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793560/ https://www.ncbi.nlm.nih.gov/pubmed/36575535 http://dx.doi.org/10.1186/s40035-022-00331-z |