The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC

Despite the strong association of the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway with tumor initiation, recurrence, and metastasis, the mechanism by which this pathway regulates cancer progression is not well understood. Here, we report that IIS supports breast cancer stem cell...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Sun, Lero, Michael W., Mercado-Matos, Jose, Zhu, Sha, Jo, Minjeong, Tocheny, Claire E., Morgan, Jennifer S., Shaw, Leslie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793643/
https://www.ncbi.nlm.nih.gov/pubmed/36476848
http://dx.doi.org/10.1016/j.celrep.2022.111759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793643/
https://www.ncbi.nlm.nih.gov/pubmed/36476848
http://dx.doi.org/10.1016/j.celrep.2022.111759

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