Biology-inspired data-driven quality control for scientific discovery in single-cell transcriptomics

BACKGROUND: Quality control (QC) of cells, a critical first step in single-cell RNA sequencing data analysis, has largely relied on arbitrarily fixed data-agnostic thresholds applied to QC metrics such as gene complexity and fraction of reads mapping to mitochondrial genes. The few existing data-dri...

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Detalles Bibliográficos
Autores principales: Subramanian, Ayshwarya, Alperovich, Mikhail, Yang, Yiming, Li, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793662/
https://www.ncbi.nlm.nih.gov/pubmed/36575523
http://dx.doi.org/10.1186/s13059-022-02820-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793662/
https://www.ncbi.nlm.nih.gov/pubmed/36575523
http://dx.doi.org/10.1186/s13059-022-02820-w

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