A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity

The bioactive sphingolipid ceramide impacts diverse cellular processes (e.g. apoptosis and cell proliferation) through its effects on membrane dynamics and intracellular signaling pathways. The dysregulation of ceramide metabolism has been implicated in cancer evasion of apoptosis and targeting cera...

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Detalles Bibliográficos
Autores principales: Morris, Siti Nur Sarah, Deol, Kirandeep K., Lange, Mike, Olzmann, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793866/
https://www.ncbi.nlm.nih.gov/pubmed/36409314
http://dx.doi.org/10.1242/bio.059695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793866/
https://www.ncbi.nlm.nih.gov/pubmed/36409314
http://dx.doi.org/10.1242/bio.059695

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