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A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity
The bioactive sphingolipid ceramide impacts diverse cellular processes (e.g. apoptosis and cell proliferation) through its effects on membrane dynamics and intracellular signaling pathways. The dysregulation of ceramide metabolism has been implicated in cancer evasion of apoptosis and targeting cera...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793866/ https://www.ncbi.nlm.nih.gov/pubmed/36409314 http://dx.doi.org/10.1242/bio.059695 |