Aeromonas hydrophila inhibits autophagy triggering cytosolic translocation of mtDNA which activates the pro-apoptotic caspase-1/IL-1β-nitric oxide axis in headkidney macrophages

The molecular mechanisms underlying Aeromonas hydrophila-pathogenesis are not well understood. Using head kidney macrophages (HKM) of Clarias gariepinus, we previously reported the role of ER-stress in A. hydrophila-induced pathogenesis. Here, we report that PI3K/PLC-induced cytosolic-Ca(2+) imbalan...

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Detalles Bibliográficos
Autores principales: Kumar, Manmohan, Shelly, Asha, Dahiya, Priyanka, Ray, Atish, Mazumder, Shibnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794009/
https://www.ncbi.nlm.nih.gov/pubmed/34967692
http://dx.doi.org/10.1080/21505594.2021.2018767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794009/
https://www.ncbi.nlm.nih.gov/pubmed/34967692
http://dx.doi.org/10.1080/21505594.2021.2018767

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