Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models

Huntington’s disease is an autosomal dominant heritable disorder caused by an expanded CAG trinucleotide repeat at the N-terminus of the Huntingtin (HTT) gene. Lowering the levels of soluble mutant HTT protein prior to aggregation through increased degradation by the proteasome would be a therapeuti...

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Detalles Bibliográficos
Autores principales: Geijtenbeek, Karlijne W., Janzen, Jolien, Bury, Aleksandra E., Sanz-Sanz, Alicia, Hoebe, Ron A., Bondulich, Marie K., Bates, Gillian P., Reits, Eric A. J., Schipper-Krom, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794069/
https://www.ncbi.nlm.nih.gov/pubmed/36574405
http://dx.doi.org/10.1371/journal.pone.0278130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794069/
https://www.ncbi.nlm.nih.gov/pubmed/36574405
http://dx.doi.org/10.1371/journal.pone.0278130

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