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Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis

Posttraumatic osteoarthritis (PTOA) is mostly treated via corticosteroid administration, and total joint arthroplasty continues to be the sole effective intervention in severe conditions. To assess the therapeutic potential of CCR2 targeting in PTOA, we used biodegradable microplates (µPLs) to achie...

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Detalles Bibliográficos
Autores principales: Ozkan, Huseyin, Di Francesco, Martina, Willcockson, Helen, Valdés-Fernández, José, Di Francesco, Valentina, Granero-Moltó, Froilán, Prósper, Felipe, Decuzzi, Paolo, Longobardi, Lara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794532/
https://www.ncbi.nlm.nih.gov/pubmed/36109442
http://dx.doi.org/10.1007/s13346-022-01235-1