Local administration of large surface area microparticle docetaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects: preclinical and clinical studies

This report describes local administration of large surface area microparticle docetaxel (LSAM-DTX: ~ 3.5- to 7.5-µm-sized particles with high relative surface area) in preclinical oncology models and in a clinical trial in urothelial carcinoma. Reductions in tumor volumes were found following intra...

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Detalles Bibliográficos
Autores principales: Maulhardt, Holly, Verco, Shelagh, Baltezor, Michael, Marin, Alyson, diZerega, Gere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794539/
https://www.ncbi.nlm.nih.gov/pubmed/36058988
http://dx.doi.org/10.1007/s13346-022-01226-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794539/
https://www.ncbi.nlm.nih.gov/pubmed/36058988
http://dx.doi.org/10.1007/s13346-022-01226-2

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