Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint

None of the current data processing pipelines for X-ray crystallography fragment-based lead discovery (FBLD) consults all the information available when deciding on the lattice and symmetry (i.e., the polymorph) of each soaked crystal. Often, X-ray crystallography FBLD pipelines either choose the po...

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Detalles Bibliográficos
Autores principales: Caputo, Alessandro T., Ibba, Roberta, Le Cornu, James D., Darlot, Benoit, Hensen, Mario, Lipp, Colette B., Marcianò, Gabriele, Vasiljević, Snežana, Zitzmann, Nicole, Roversi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794592/
https://www.ncbi.nlm.nih.gov/pubmed/36589243
http://dx.doi.org/10.3389/fmolb.2022.960248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794592/
https://www.ncbi.nlm.nih.gov/pubmed/36589243
http://dx.doi.org/10.3389/fmolb.2022.960248

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