Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids

PARPs play fundamental roles in multiple DNA damage recognition and repair pathways. Persistent nuclear PARP activation causes cellular NAD(+) depletion and exacerbates cellular aging. However, very little is known about mitochondrial PARP (mtPARP) and poly ADP-ribosylation (PARylation). The existen...

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Detalles Bibliográficos
Autores principales: Lee, Jong-Hyuk, Hussain, Mansoor, Kim, Edward W., Cheng, Shang-Jung, Leung, Anthony K. L., Fakouri, Nima Borhan, Croteau, Deborah L., Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794712/
https://www.ncbi.nlm.nih.gov/pubmed/36473936
http://dx.doi.org/10.1038/s12276-022-00894-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794712/
https://www.ncbi.nlm.nih.gov/pubmed/36473936
http://dx.doi.org/10.1038/s12276-022-00894-x

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