Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines

To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccine antigen. We investigated how formulation affects...

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Detalles Bibliográficos
Autores principales: Tregoning, John S., Stirling, David C., Wang, Ziyin, Flight, Katie E., Brown, Jonathan C., Blakney, Anna K., McKay, Paul F., Cunliffe, Robert F., Murugaiah, Valarmathy, Fox, Christopher B., Beattie, Mitchell, Tam, Ying K., Johansson, Cecilia, Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794906/
https://www.ncbi.nlm.nih.gov/pubmed/36589712
http://dx.doi.org/10.1016/j.omtn.2022.11.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794906/
https://www.ncbi.nlm.nih.gov/pubmed/36589712
http://dx.doi.org/10.1016/j.omtn.2022.11.024

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