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A synthetic human 3D in vitro lymphoid model enhancing B-cell survival and functional differentiation

To investigate B-cell differentiation and maturation occurring in the germinal center (GC) using in vitro culture systems, key factors and interactions of the GC reaction need to be accurately simulated. This study aims at improving in vitro GC simulation using 3D culture techniques. Human B-cells w...

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Detalles Bibliográficos
Autores principales: Braham, Maaike V.J., van Binnendijk, Rob S., Buisman, Anne-Marie M., Mebius, Reina E., de Wit, Jelle, van Els, Cécile A.C.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794978/
https://www.ncbi.nlm.nih.gov/pubmed/36590159
http://dx.doi.org/10.1016/j.isci.2022.105741