Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination

The generation of high-affinity antibodies requires an efficient germinal center (GC) response. As differentiating B cells cycle between GC dark and light zones they encounter different oxygen pressures (pO(2)). However, it is essentially unknown if and how variations in pO(2) affect B cell differen...

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Detalles Bibliográficos
Autores principales: Koers, Jana, Marsman, Casper, Steuten, Juulke, Tol, Simon, Derksen, Ninotska I. L., ten Brinke, Anja, van Ham, S. Marieke, Rispens, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795029/
https://www.ncbi.nlm.nih.gov/pubmed/36591315
http://dx.doi.org/10.3389/fimmu.2022.1082154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795029/
https://www.ncbi.nlm.nih.gov/pubmed/36591315
http://dx.doi.org/10.3389/fimmu.2022.1082154

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