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Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination
The generation of high-affinity antibodies requires an efficient germinal center (GC) response. As differentiating B cells cycle between GC dark and light zones they encounter different oxygen pressures (pO(2)). However, it is essentially unknown if and how variations in pO(2) affect B cell differen...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795029/ https://www.ncbi.nlm.nih.gov/pubmed/36591315 http://dx.doi.org/10.3389/fimmu.2022.1082154 |