Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss

Hearing loss is the most common sensory deficit, of which genetic etiologies are a frequent cause. Dominant and recessive mutations in TMC1, a gene encoding the pore-forming subunit of the hair cell mechanotransduction channel, cause DFNA36 and DFNB7/11, respectively, accounting for ∼2% of genetic h...

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Detalles Bibliográficos
Autores principales: Iwasa, Yoichiro, Klimara, Miles J, Yoshimura, Hidekane, Walls, William D, Omichi, Ryotaro, West, Cody A, Shibata, Seiji B, Ranum, Paul T, Smith, Richard JH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795038/
https://www.ncbi.nlm.nih.gov/pubmed/36574989
http://dx.doi.org/10.26508/lsa.202201592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795038/
https://www.ncbi.nlm.nih.gov/pubmed/36574989
http://dx.doi.org/10.26508/lsa.202201592

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