De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs

Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST silencing, causing challenges in various applications of female hPSCs. Here, we report reliable methods to reactivate XIST with monoallelic express...

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Detalles Bibliográficos
Autores principales: Motosugi, Nami, Sugiyama, Akiko, Okada, Chisa, Otomo, Asako, Umezawa, Akihiro, Akutsu, Hidenori, Hadano, Shinji, Fukuda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795333/
https://www.ncbi.nlm.nih.gov/pubmed/36590687
http://dx.doi.org/10.1016/j.crmeth.2022.100352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795333/
https://www.ncbi.nlm.nih.gov/pubmed/36590687
http://dx.doi.org/10.1016/j.crmeth.2022.100352

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