Cargando…
Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair
In both humans and mice, repair of acute kidney injury is worse in males than in females. Here, we provide evidence that this sexual dimorphism results from sex differences in ferroptosis, an iron-dependent, lipid-peroxidation-driven regulated cell death. Using genetic and single-cell transcriptomic...
Autores principales: | Ide, Shintaro, Ide, Kana, Abe, Koki, Kobayashi, Yoshihiko, Kitai, Hiroki, McKey, Jennifer, Strausser, Sarah A., O’Brien, Lori L., Tata, Aleksandra, Tata, Purushothama Rao, Souma, Tomokazu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795409/ https://www.ncbi.nlm.nih.gov/pubmed/36351395 http://dx.doi.org/10.1016/j.celrep.2022.111610 |
Ejemplares similares
-
Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair
por: Ide, Shintaro, et al.
Publicado: (2021) -
Yolk-sac-derived macrophages progressively expand in the mouse kidney with age
por: Ide, Shintaro, et al.
Publicado: (2020) -
Sertoli cell ablation and replacement of the spermatogonial niche in mouse
por: Yokonishi, Tetsuhiro, et al.
Publicado: (2020) -
Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis
por: Tao, Hui, et al.
Publicado: (2023) -
Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures
por: Konishi, Satoshi, et al.
Publicado: (2022)