Backbone N-Amination Promotes the Folding of β-Hairpin Peptides via a Network of Hydrogen Bonds

[Image: see text] Molecular dynamics (MD) simulations have been used to characterize the effects of backbone N-amination of residues in a model β-hairpin peptide. This modification is of considerable interest as N-aminated peptides have been shown to inhibit amyloid-type aggregation. Six derivatives...

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Detalles Bibliográficos
Autores principales: Dolenc, Jožica, Haywood, Esme J., Zhu, Tingting, Smith, Lorna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795546/
https://www.ncbi.nlm.nih.gov/pubmed/35816656
http://dx.doi.org/10.1021/acs.jcim.2c00516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795546/
https://www.ncbi.nlm.nih.gov/pubmed/35816656
http://dx.doi.org/10.1021/acs.jcim.2c00516

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