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Backbone N-Amination Promotes the Folding of β-Hairpin Peptides via a Network of Hydrogen Bonds
[Image: see text] Molecular dynamics (MD) simulations have been used to characterize the effects of backbone N-amination of residues in a model β-hairpin peptide. This modification is of considerable interest as N-aminated peptides have been shown to inhibit amyloid-type aggregation. Six derivatives...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795546/ https://www.ncbi.nlm.nih.gov/pubmed/35816656 http://dx.doi.org/10.1021/acs.jcim.2c00516 |