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Protein import into peroxisomes occurs through a nuclear pore-like phase

Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases. Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble receptor PEX5. How folded cargo crosses the membrane is unknown. Here, we show that peroxisomal import is similar to nuclear t...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Skowyra, Michael L., Feng, Peiqiang, Rapoport, Tom A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795577/
https://www.ncbi.nlm.nih.gov/pubmed/36520918
http://dx.doi.org/10.1126/science.adf3971