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Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration
BACKGROUND: The strongest risk factor of neurodegenerative diseases (NDDs) is aging. Spontaneous asparaginyl deamidation leading to formation of isoaspartate (isoAsp) has been correlated with protein aggregation in NDDs. METHODS: Two cohorts consisting of 140 subjects were studied. Cohort 1 containe...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795668/ https://www.ncbi.nlm.nih.gov/pubmed/36575499 http://dx.doi.org/10.1186/s40364-022-00435-8 |