Status of treatment strategies for Hutchinson–Gilford progeria syndrome with a focus on prelamin: A posttranslational modification

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature ageing and early death at a mean age of 14.7 years. At the molecular level, HGPS is caused by a de novo heterozygous mutation in LMNA, the gene encoding A‐type lamins (mainly lamin A and C) and nuclear...

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Detalles Bibliográficos
Autores principales: Chen, Xue, Yao, Haidong, Andrés, Vicente, Bergo, Martin O., Kashif, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
MINI REVIEW
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795874/
https://www.ncbi.nlm.nih.gov/pubmed/35790078
http://dx.doi.org/10.1111/bcpt.13770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795874/
https://www.ncbi.nlm.nih.gov/pubmed/35790078
http://dx.doi.org/10.1111/bcpt.13770

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